Infection markers as predictors of Bacteremia in an Intensive Care Unit: A prospective study
| Autor: | Mehmet Kizilkaya, Salih Atakan Nemli, Ilknur Vardar, Huriye Erbak Yilmaz, Atilla Sencan, Pinar Sen, Tuna Demirdal |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Bacteremia Neopterin Procalcitonin law.invention Sepsis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine law Internal medicine medicine Intensive care unit Blood culture 030212 general & internal medicine Prospective cohort study Pro-adrenomedullin medicine.diagnostic_test Septic shock business.industry Neutrophil to lymphocyte ratio 030208 emergency & critical care medicine General Medicine bacterial infections and mycoses medicine.disease chemistry Original Article business |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X |
| Popis: | Objective: Although several biomarkers have been evaluated for the diagnosis and prognosis of sepsis, the gold standard biomarker has not yet been found. We aimed to evaluate the diagnostic value of neutrophil-to-lymphocyte count ratio (NLCR), neopterin, pro-adrenomedullin (pro-ADM) and the other infection markers to predict bacteremia in patients with SIRS, sepsis and severe sepsis/septic shock. Methods: A prospective cohort study was conducted on septic patients in a tertiary referral hospital between December 2014- July 2015. A total of 156 patients diagnosed with SIRS, sepsis and severe sepsis/septic shock in Anesthesia intensive care unit (ICU) were included in the study. Results: A total of 156 patients who had been diagnosed as SIRS(10.9%), sepsis (44.2%) and severe sepsis/septic shock (44.9%) were included. Positive blood cultures were obtained in 64 patients. NLCR, neopterin and pro-ADM levels were insignificant in predicting bacteremia (p>0.05). The mortality rate was significantly higher in bacteremic sepsis (43.9%) compared to non-bacteremic patients (20.8%) (p=0.001). Only procalcitonin levels were significant predictor of mortality (p |
| Databáze: | OpenAIRE |
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