Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia
Autor: | Safinaz Hussein, Eman Mosaad Zaki, Asmaa M Zahran, Abdallah Elaiw Mohammed, Alshimaa Abdelazeem Metwaly, Rania Hafez |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
CD4-Positive T-Lymphocytes Male T cell Chronic lymphocytic leukemia Cell CD38 lcsh:RC254-282 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Immunophenotyping immune system diseases hemic and lymphatic diseases Medicine Humans Prospective Studies Aged Aged 80 and over business.industry lcsh:RC633-647.5 Apyrase Hematology General Medicine lcsh:Diseases of the blood and blood-forming organs Middle Aged medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Leukemia Lymphocytic Chronic B-Cell Neoplasm Proteins Gene Expression Regulation Neoplastic Adenosine diphosphate medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis Immunology Chromosomes Human Pair 6 Female Bone marrow Chromosome Deletion business 030215 immunology |
Zdroj: | Hematology/Oncology and Stem Cell Therapy, Vol 12, Iss 1, Pp 26-31 (2019) |
ISSN: | 1658-3876 |
Popis: | Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune system. We investigated expression of CD39 on CD4+ T Lymphocytes in chronic lymphocytic leukemia (CLL) patients and its relationship with deletion 6q, its association with disease stage and survival. Methods: Thirty CLL patients and 20 matched controls were included in the study. Bone marrow studies with immunophenotyping, CD39, CD38, and ZAP-70, and detection of del 6q by FISH were performed. Results: CD39+ CD4+ T helper cells in CLL patients were significantly expressed compared with the controls (p |
Databáze: | OpenAIRE |
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