Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Autor: Safinaz Hussein, Eman Mosaad Zaki, Asmaa M Zahran, Abdallah Elaiw Mohammed, Alshimaa Abdelazeem Metwaly, Rania Hafez
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
CD4-Positive T-Lymphocytes
Male
T cell
Chronic lymphocytic leukemia
Cell
CD38
lcsh:RC254-282
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Immune system
Immunophenotyping
immune system diseases
hemic and lymphatic diseases
Medicine
Humans
Prospective Studies
Aged
Aged
80 and over
business.industry
lcsh:RC633-647.5
Apyrase
Hematology
General Medicine
lcsh:Diseases of the blood and blood-forming organs
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Leukemia
Lymphocytic
Chronic
B-Cell
Neoplasm Proteins
Gene Expression Regulation
Neoplastic
Adenosine diphosphate
medicine.anatomical_structure
Oncology
chemistry
030220 oncology & carcinogenesis
Immunology
Chromosomes
Human
Pair 6
Female
Bone marrow
Chromosome Deletion
business
030215 immunology
Zdroj: Hematology/Oncology and Stem Cell Therapy, Vol 12, Iss 1, Pp 26-31 (2019)
ISSN: 1658-3876
Popis: Objective/Background: Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune system. We investigated expression of CD39 on CD4+ T Lymphocytes in chronic lymphocytic leukemia (CLL) patients and its relationship with deletion 6q, its association with disease stage and survival. Methods: Thirty CLL patients and 20 matched controls were included in the study. Bone marrow studies with immunophenotyping, CD39, CD38, and ZAP-70, and detection of del 6q by FISH were performed. Results: CD39+ CD4+ T helper cells in CLL patients were significantly expressed compared with the controls (p
Databáze: OpenAIRE
Externí odkaz: