BMI and BMD: The Potential Interplay between Obesity and Bone Fragility
| Autor: | Nicola Napoli, Dario Tuccinardi, Paolo Pozzilli, Andrea Palermo, Giuseppe Defeudis, Luca D'Onofrio, Silvia Manfrini, Mikiko Watanabe, Angelo Lauria Pantano |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty obesity Bone density Health Toxicology and Mutagenesis Osteoporosis Adipokine Adipose tissue lcsh:Medicine 030209 endocrinology & metabolism Review White adipose tissue Bioinformatics Bone resorption Body Mass Index 03 medical and health sciences 0302 clinical medicine Adipokines Bone Density Internal medicine Humans Medicine Bone Resorption Metabolic Syndrome body composition business.industry lcsh:R Public Health Environmental and Occupational Health medicine.disease Obesity osteoporosis 030104 developmental biology Endocrinology Adipose Tissue inflammation fracture Inflammation Mediators Metabolic syndrome business |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 13, Iss 6, p 544 (2016) International Journal of Environmental Research and Public Health |
| ISSN: | 1660-4601 |
| Popis: | Recent evidence demonstrating an increased fracture risk among obese individuals suggests that adipose tissue may negatively impact bone health, challenging the traditional paradigm of fat mass playing a protective role towards bone health. White adipose tissue, far from being a mere energy depot, is a dynamic tissue actively implicated in metabolic reactions, and in fact secretes several hormones called adipokines and inflammatory factors that may in turn promote bone resorption. More specifically, Visceral Adipose Tissue (VAT) may potentially prove detrimental. It is widely acknowledged that obesity is positively associated to many chronic disorders such as metabolic syndrome, dyslipidemia and type 2 diabetes, conditions that could themselves affect bone health. Although aging is largely known to decrease bone strength, little is yet known on the mechanisms via which obesity and its comorbidities may contribute to such damage. Given the exponentially growing obesity rate in recent years and the increased life expectancy of western countries it appears of utmost importance to timely focus on this topic. |
| Databáze: | OpenAIRE |
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