Effects of psychostimulants on social interaction in adult male rats
Autor: | I. Hrebíčková, Kateryna Nohejlová, E. Macúchová, Mária Ševčíková, Anna Mikulecká, Marie Pometlová, Romana Šlamberová |
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Rok vydání: | 2015 |
Předmět: |
Male
medicine.medical_specialty Adult male medicine.medical_treatment N-Methyl-3 4-methylenedioxyamphetamine Social behaviour Motor Activity Cocaine Sniffing Internal medicine medicine Animals Interpersonal Relations Rats Wistar Amphetamine Saline Pharmacology Behavior Animal Dose-Response Relationship Drug business.industry MDMA Social relation Rats Psychiatry and Mental health Dose–response relationship Endocrinology Central Nervous System Stimulants business Locomotion medicine.drug |
Zdroj: | Behavioural pharmacology. 26(8 Spec) |
ISSN: | 1473-5849 |
Popis: | Psychostimulants are known to have a huge impact on different forms of social behaviour. The aim of the present study was to compare the effects of three different psychostimulants [amphetamine, cocaine and 3,4 methylenedimethoxyamphetamine (MDMA)] on social interaction (SI) in adult male rats. The SI test was performed in a familiar arena and under low-stress environmental conditions. Experimental animals received amphetamine (0.5, 1.0, 1.5 mg/kg), cocaine (0.5, 1.0, 1.5, 2.5, 5.0, 10.0 mg/kg) or MDMA (2.5, 5.0, 10 mg/kg) and control animals received saline (1 ml/kg) 45 min before the SI test. Time spent in SI (individual patterns of social behaviour) and nonsocial activities (locomotion and rearing) were video recorded and then analysed offline, with the following results: (a) all doses of amphetamine decreased SI. Specifically, all doses of amphetamine decreased mutual sniffing, and the higher doses also decreased allo-grooming and following behaviours. (b) The higher doses of cocaine decreased SI, especially mutual sniffing, allo-grooming and climbing over. Cocaine at the dose of 5.0 mg/kg increased genital investigation compared with lower doses. (c) All doses of MDMA decreased mutual sniffing and climbing over; the two higher doses decreased allo-grooming behaviour, and only the highest dose decreased following. The two higher doses of amphetamine and all the doses of MDMA increased locomotion and rearing; cocaine did not affect locomotion, but increased rearing at higher doses. In conclusion, the results confirm the well-known finding that psychostimulants suppress SI, but also show novel differences in the effects of psychostimulants on specific patterns of SI. |
Databáze: | OpenAIRE |
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