Immunological Aspects of Isolation and Confinement

Autor: A. A. Sadova, M. P. Rykova, S. A. Ponomarev, Sergey Kalinin, K.D. Orlova, Brian Crucian
Rok vydání: 2021
Předmět:
Adult
Male
0301 basic medicine
Time Factors
Computer science
media_common.quotation_subject
Immunology
Crew
Antarctic Regions
Outer space
Context (language use)
Review
Adaptive Immunity
Space (commercial competition)
Young Adult
03 medical and health sciences
Confined Spaces
0302 clinical medicine
Stress
Physiological
Humans
Immunology and Allergy
Computer Simulation
space flight
Spacecraft
innate immunity
immunology of confinement
media_common
Immune status
Microbiota
RC581-607
Middle Aged
Acquired immune system
Functional system
Immunity
Innate
ground-based analogues
030104 developmental biology
Risk analysis (engineering)
Immune System
Isolation (psychology)
Astronauts
Female
Immunologic diseases. Allergy
Space Research
Ecological Systems
Closed
Space Simulation
Stress
Psychological
030217 neurology & neurosurgery
Zdroj: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
ISSN: 1664-3224
DOI: 10.3389/fimmu.2021.697435
Popis: Beyond all doubts, the exploration of outer space is a strategically important and priority sector of the national economy, scientific and technological development of every and particular country, and of all human civilization in general. A number of stress factors, including a prolonged confinement in a limited hermetically sealed space, influence the human body in space on board the spaceship and during the orbital flight. All these factors predominantly negatively affect various functional systems of the organism, in particular, the astronaut’s immunity. These ground-based experiments allow to elucidate the effect of confinement in a limited space on both the activation of the immunity and the changes of the immune status in dynamics. Also, due to simulation of one or another emergency situation, such an approach allows the estimation of the influence of an additional psychological stress on the immunity, particularly, in the context of the reserve capacity of the immune system. A sealed chamber seems a convenient site for working out the additional techniques for crew members selection, as well as the countermeasures for negative changes in the astronauts’ immune status. In this review we attempted to collect information describing changes in human immunity during isolation experiments with different conditions including short- and long-term experiments in hermetically closed chambers with artificial environment and during Antarctic winter-over.
Databáze: OpenAIRE
Externí odkaz: