Genotoxic effects of Tabebuia impetiginosa (Mart. Ex DC.) Standl. (Lamiales, Bignoniaceae) extract in Wistar rats
| Autor: | Márcio Luis Andrade e Silva, Mireille A.P. Felix, Odilon A. Lemos, Adriana H. C. Vinholis, Raquel Alves dos Santos, Ícaro E. F. Silva, Júlio C.M. Sanches, Andréa O. Cecchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Traditional medicine
lcsh:QH426-470 DNA damage Tabebuia impetiginosa Negative control Bignoniaceae Lamiales Biology biology.organism_classification Tabebuia Comet assay Wistar rats lcsh:Genetics Mutagenesis comet assay visual_art Botany Genetics visual_art.visual_art_medium natural compounds Bark Molecular Biology Research Article |
| Zdroj: | Genetics and Molecular Biology, Vol 35, Iss 2, Pp 498-502 (2012) Genetics and Molecular Biology v.35 n.2 2012 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG Genetics and Molecular Biology, Volume: 35, Issue: 2, Pages: 498-502, Published: 17 MAY 2012 |
| ISSN: | 1678-4685 1415-4757 |
| Popis: | Tabebuia sp. is native to tropical rain forests throughout Central and South America. Although the biological and pharmacological effects of bark extracts have been intensely studied, little is known on the extract obtained from the flower. Herein, the genotoxic potential of a flower extract from T. impetiginosa ("ipê roxo") on the blood and liver cells of Wistar rats was evaluated. Experimental procedures involved only male animals. Graduated concentrations of the extract, viz., 100, 300 and 500 mg kg(-1) of body weight, were gavage-administered and 24 h latter cells were collected and processed for analysis. With the exception of the 100 mg kg(-1) dose, a significant increase in DNA damage was noted, when compared with a negative control group. Although the genotoxic potential of this extract was higher in liver cells, the response in both tissues was related to dose-dependency. Even though DNA damage can be corrected before conversion into mutations, further study is recommended to arrive at a better understanding of incurred biological effects. |
| Databáze: | OpenAIRE |
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