Structural, mechanical and swelling characteristics of 3D scaffolds from chitosan-agarose blends
| Autor: | Mark J. Gideon-Adeniyi, Reda M. Felfel, Kazi M. Zakir Hossain, David M. Grant, George A. F. Roberts |
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| Rok vydání: | 2019 |
| Předmět: |
Scaffold
Materials science Polymers and Plastics Organic Chemistry technology industry and agriculture 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Compression (physics) 01 natural sciences 0104 chemical sciences Chitosan chemistry.chemical_compound Compressive strength chemistry Chemical engineering Materials Chemistry medicine Agarose Swelling medicine.symptom Fourier transform infrared spectroscopy 0210 nano-technology Porosity |
| Zdroj: | Carbohydrate Polymers. 204:59-67 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2018.10.002 |
| Popis: | This study aimed to explore the correlation between mechanical and structural properties of chitosan-agarose blend (Ch-Agrs) scaffolds. Porosity of Ch-Agrs scaffolds was constant at 93%, whilst pore sizes varied between 150 and 550 μm. Pore sizes of the blend scaffolds (150–300 μm) were significantly smaller than for either agarose or chitosan scaffolds alone (ca. 500 μm). Ch50-Agrs50 blend scaffold showed the highest compressive modulus and strength values (4.5 ± 0.4 and 0.35 ± 0.03 MPa) due to reduction in the pore size. The presence of agarose improved the stability of the blends in aqueous media. The increase in compressive properties and residual weight after the TGA test, combined with the reduction in the swelling percentage of the blend scaffolds suggested an interaction between chitosan and agarose via hydrogen bonding which was confirmed using FTIR analysis. All wet blend scaffolds exhibited instant recovery after full compression. This study shows the potential of Ch-Agrs scaffolds for repairing soft tissue. |
| Databáze: | OpenAIRE |
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