Changes in Maternal Lipid Peroxidation Levels and Antioxidant Enzymatic Activities Before and After Delivery
| Autor: | Tsutomu Araki, Atsuko Oya, Akishige Yokota, Hirobumi Asakura, Hitoshi Kobe, Akihito Nakai, Tatsuo Koshino |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Antioxidant medicine.medical_treatment medicine.disease_cause Andrology Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Pregnancy medicine Humans reproductive and urinary physiology chemistry.chemical_classification Reactive oxygen species Labor Obstetric biology Superoxide Dismutase business.industry Glutathione peroxidase Postpartum Period Infant Newborn General Medicine Catalase Malondialdehyde Oxidative Stress chemistry Immunology biology.protein Female Lipid Peroxidation Reactive Oxygen Species business Oxidative stress |
| Zdroj: | Journal of Nippon Medical School. 67:434-439 |
| ISSN: | 1347-3409 1345-4676 |
| Popis: | Objective: Our goal was to characterize the changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery. Methods: Predelivery and 124 and 48 hours post‑partum plasma concentrations of malon‑ dialdehyde erythrocyte enzyme superoxide dismutase glutathione peroxidase and catalase were measured in uncomplicated pregnancies. Results: Malondialdehyde levels increased slightly from predelivery to 24 hours post‑partum and then decreased significantly at 48 hours post‑partum. At one hour post‑partum superoxide dismutase and catalase levels increased significantly to about 125% and 170% of predelivery lev‑ els respectively. Thereafter these values decreased significantly from one hour to 48 hours post‑ partum. The relative changes in superoxide dismutase and catalase levels at one hour post‑ partum compared to predelivery values correlated significantly with the duration of labor. Conclusion: The results suggest that the uncontrolled lipid peroxidatio nc aused by reactive oxygen species which are produced in consequence of tissue reoxygenation may occur during labor and that prolonged labor may cause maternal oxidative stress. (J Nippon Med Sch 2000; 67: 434―439) |
| Databáze: | OpenAIRE |
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