Influence of Alpha-Adrenoceptor Blockade with Thymoxamine on Changes in Pupil Diameter and Accommodation Produced by Tropicamide and Ephedrine

Autor:	Gillian L. Mayer, J. H. Stewart-Jones, Paul Turner
Rok vydání:	1977
Předmět:	Adult Ephedrine Mydriatics Pyridines Tropicamide business.industry Pupil diameter Accommodation Ocular Pupil General Medicine Sodium Chloride Blockade Ophthalmic solutions Moxisylyte Anesthesia Healthy volunteers medicine Mydriasis Humans Alpha adrenoceptor medicine.symptom business medicine.drug
Zdroj:	Current Medical Research and Opinion. 4:660-664
ISSN:	1473-4877 0300-7995
DOI:	10.1185/03007997709115288
Popis:	In a study in 12 healthy volunteers, local instillation of thymoxamine eye-drops (0.2%) completely reversed the mydriasis produced by ephedrine (5%) but not that produced by ephedrine (5%) together with tropicamide (0.5%). Small but significant changes in accommodation were found with ephedrine and reversed by thymoxamine, suggesting that they were mediated through alpha-adrenoceptor activity. The thymoxamine eyedrops were well tolerated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2a45971992d07f88a0c77f03551a7b https://doi.org/10.1185/03007997709115288 Zobrazit plný text záznamu