Magnetic resonance imaging-based detection of glial brain tumors in mice after antiangiogenic treatment

Autor: Arend Heerschap, Cathy Maass, Giulio Gambarota, Pieter Wesseling, Olaf van Tellingen, An Claes, Bob C. Hamans, William P.J. Leenders
Rok vydání: 2008
Předmět:
Gadolinium DTPA
Cancer Research
Pathology
Angiogenesis
Administration
Oral
Contrast Media
Angiogenesis Inhibitors
Blood volume
Aetiology
screening and detection [ONCOL 5]
Vandetanib
Mice
Piperidines
Magnetite Nanoparticles
Molecular diagnosis
prognosis and monitoring [UMCN 1.2]
Mice
Inbred BALB C
medicine.diagnostic_test
Brain Neoplasms
Dextrans
Oxides
Glioma
Immunohistochemistry
Magnetic Resonance Imaging
Extravasation
medicine.anatomical_structure
Mitochondrial medicine [IGMD 8]
Oncology
Blood-Brain Barrier
Functional Neurogenomics [DCN 2]
medicine.drug
Chemical and physical biology [NCMLS 7]
medicine.medical_specialty
Energy and redox metabolism [NCMLS 4]
Iron
Transplantation
Heterologous
Mice
Nude
Blood–brain barrier
Predictive Value of Tests
Translational research [ONCOL 3]
medicine
Animals
business.industry
Microcirculation
Cancer
Magnetic resonance imaging
medicine.disease
Tissue engineering and pathology [NCMLS 3]
Ferrosoferric Oxide
Tumor microenvironment [UMCN 1.3]
Quinazolines
Functional Imaging [UMCN 1.1]
business
Immunity
infection and tissue repair [NCMLS 1]
Zdroj: International Journal of Cancer, 122, 1981-6
International Journal of Cancer, 122, 9, pp. 1981-6
ISSN: 0020-7136
Popis: Contains fulltext : 69111.pdf (Publisher’s version ) (Closed access) Proper delineation of gliomas using contrast-enhanced magnetic resonance imaging (CE-MRI) poses a problem in neuro-oncology. The blood brain barrier (BBB) in areas of diffuse-infiltrative growth may be intact, precluding extravasation and subsequent MR-based detection of the contrast agent gadolinium diethylenetriaminepenta-acetic acid (Gd-DTPA). Treatment with antiangiogenic compounds may further complicate tumor detection as such compounds can restore the BBB in angiogenic regions. The increasing number of clinical trials with antiangiogenic compounds for treatment of gliomas calls for the development of alternative imaging modalities. Here we investigated whether CE-MRI using ultrasmall particles of iron oxide (USPIO, Sinerem) as blood pool contrast agent has additional value for detection of glioma in the brain of nude mice. We compared conventional T1-weighted Gd-DTPA-enhanced MRI to T2*-weighted USPIO-enhanced MRI in mice carrying orthotopic U87 glioma, which were either or not treated with the antiangiogenic compound vandetanib (ZD6474, ZACTIMA). In untreated animals, vessel leakage within the tumor and a relatively high tumor blood volume resulted in good MRI visibility with Gd-DTPA- and USPIO-enhanced MRI, respectively. Consistent with previous findings, vandetanib treatment restored the BBB in the tumor vasculature, resulting in loss of tumor detectability in Gd-DTPA MRI. However, due to decreased blood volume, treated tumors could be readily detected in USPIO-enhanced MRI scans. Our findings suggest that Gd-DTPA MRI results in overestimation of the effect of antiangiogenic therapy of glioma and that USPIO-MRI provides an important complementary diagnostic tool to evaluate response to antiangiogenic therapy of these tumors.
Databáze: OpenAIRE
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