Parameters of hormetic stress and resilience to trauma in rats
| Autor: | Traci N Plumb, Patrick K. Cullen, Thomas R. Minor |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Restraint Physical medicine.medical_specialty Time Factors Physiology media_common.quotation_subject Learned helplessness Motor Activity Rats Sprague-Dawley Behavioral Neuroscience Physical medicine and rehabilitation Hormesis Helplessness Learned Escape Reaction Stress (linguistics) Conditioning Psychological medicine Reaction Time Animals Fear conditioning media_common Electroshock Endocrine and Autonomic Systems Stressor Traumatic stress Fear Resilience Psychological Psychiatry and Mental health Disease Models Animal Neuropsychology and Physiological Psychology Psychological resilience Restraint stress Psychology Stress Psychological Clinical psychology |
| Zdroj: | Stress (Amsterdam, Netherlands). 18(1) |
| ISSN: | 1607-8888 |
| Popis: | Hormesis is the process by which small stresses build resilience to large stresses. We pre-exposed rats to various parameters of mild-to-moderate stress prior to traumatic stress in the present experiments to assess the potential benefits of hormetic training on resilience to traumatic, uncontrollable stress. Rats underwent varying stress pre-training parameters prior to exposure to uncontrollable traumatic stress in the learned helplessness procedure. The ability to prevent the exaggerated fear responding and escape deficits that normally follow experience with traumatic stress were used as a measure of the benefits of hormetic training. Four experiments examined the effects of number of training sessions, stressor severity and pattern of rest between pre-training stress sessions. Repeated exposure to mild restraint stress or moderate shock stress eliminated both the enhanced fear conditioning and shuttle-escape deficits that result from exposure to traumatic, inescapable shock. The pattern of rest did not contribute to resilience when the pre-exposure stressor was mild, but was vital when the pre-exposure stressor was moderate, with an alternation of stress and rest being the most effective procedure. The data also suggest that the level of resilience may increase with the number of pre-exposure sessions. |
| Databáze: | OpenAIRE |
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