Ugt1A1*28 Polymorphism and Vomiting in Advanced Colorectal Cancer
| Autor: | Abeer A. Bahnasy, Ahmed El Bastawisy, Amany El-Zeiny, Samar F. Farid |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Gynecology
Oncology Cancer Research medicine.medical_specialty Colorectal cancer business.industry UGT1A1*28 polymorphism Hematology Neutropenia medicine.disease Gastroenterology Advanced colorectal cancer Diarrhea Polymorphism (computer science) Internal medicine medicine Vomiting medicine.symptom business |
| Zdroj: | Annals of Oncology. 24:iv93 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdt203.203 |
| Popis: | e14678 Background: UGT1A1*28 polymorphism is associated with neutropenia and diarrhea in previous reports, this study tried to investigate correlation with other toxicities like vomiting. Methods: This is a prospective case control study including all eligible cases of advanced colorectal cancer. The genotypes of UGT1A1*28 was assessed in the peripheral blood and/or in tissues by PCR. Patients were divided into two groups, group1: patients with no or hetero mutation, group 2: patients with homo mutation. All patients received standard IFL regimen. Primary endpoints were: 1-comparison between the 2 groups as regard vomiting .2-assessement of the incidence of UGT1A1*28 polymorphism. Secondary endpoints were: comparison between the 2 groups as regard: neutropenia, diarrhea, progressive diseases (PD), progression free survival (PFS) and overall survival (OS). Results: 43 cases of advanced colorectal cancer aged between 19 and 68 years with a median age of 45 years were included and followed up during the period from September 2010 to January 2013 with a median follow up of 9 months. UGT1A1*28 polymorphism were present in 21 patients (42%) of them 14% are homozygous. Grade (II-III) vomiting was found in 18.9% of group 1 versus 66.7% of group2. (P=0.03).Grade (II-IV) neutropenia were found in 27% of group 1 versus 83.4% of group2. (P=0.01). Grade (II-III) diarrhea was found in 37.8% of patients of group1 and 16.7% of patients with group 2. (P=0.44).20% of group 1 showed PD versus 40% of group 2. (P=0.5).1year PFS was 19% in group 1 versus 0% in group 2. (P= 0.74) while there was a trend towards better OS in group 1 (47% versus 0%). (P= 0.0892). Conclusions: UGT1A1*28 polymorphism is present frequently (42%) in a Caucasian population and is associated with more vomiting and neutropenia. |
| Databáze: | OpenAIRE |
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