Links between gut microbiome composition and fatty liver disease in a large population sample
| Autor: | Ville Männistö, Matti O. Ruuskanen, Mohit Jain, Leo Lahti, Fredrik Åberg, Pekka Jousilahti, Guillaume Méric, Rohit Loomba, Yoshiki Vázquez-Baeza, Yang Liu, Teemu J. Niiranen, Michael Inouye, Aki S. Havulinna, Anupriya Tripathi, Rob Knight, Veikko Salomaa, Liisa Valsta |
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| Přispěvatelé: | Clinicum, HUS Abdominal Center, IV kirurgian klinikka, Helsinki University Hospital Area, University of Helsinki, Medicum, Institute for Molecular Medicine Finland, Complex Disease Genetics, Helsinki Institute of Life Science HiLIFE |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Population sample fatty liver index Physiology RC799-869 Disease Oral and gastrointestinal Cohort Studies Liver disease 0302 clinical medicine Phylogeny 11832 Microbiology and virology 0303 health sciences education.field_of_study Genome Liver Disease Fatty liver Gastroenterology Age Factors Bacterial Middle Aged Diseases of the digestive system. Gastroenterology Infectious Diseases Female 030211 gastroenterology & hepatology Research Article Research Paper human gut Microbiology (medical) Adult Chronic Liver Disease and Cirrhosis Population Large population Biology Microbiology 03 medical and health sciences Human gut Sex Factors Liver steatosis Genetics medicine Humans population sample education fatty liver 030304 developmental biology Clostridium Bacteria Ethanol Human Genome medicine.disease Gut microbiome Gastrointestinal Microbiome 030104 developmental biology Good Health and Well Being Metagenomics 3121 General medicine internal medicine and other clinical medicine Fermentation Metagenome Digestive Diseases Genome Bacterial |
| Zdroj: | Gut Microbes, Vol 13, Iss 1 (2021) Gut microbes, vol 13, iss 1 Gut Microbes article-version (VoR) Version of Record |
| DOI: | 10.1101/2020.07.30.20164962 |
| Popis: | Fatty liver disease is the most common liver disease in the world. It is characterized by a buildup of excess fat in the liver that can lead to cirrhosis and liver failure. The link between fatty liver disease and gut microbiome has been known for at least 80 years. However, this association remains mostly unstudied in the general population because of underdiagnosis and small sample sizes. To address this knowledge gap, we studied the link between the Fatty Liver Index (FLI), a well-established proxy for fatty liver disease, and gut microbiome composition in a representative, ethnically homogeneous population sample in Finland. We based our models on biometric covariates and gut microbiome compositions from shallow metagenome sequencing. Our classification models could discriminate between individuals with a high FLI (≥ 60, indicates likely liver steatosis) and low FLI (< 60) in our validation set, consisting of 30% of the data not used in model training, with an average AUC of 0.75. In addition to age and sex, our models included differences in 11 microbial groups from class Clostridia, mostly belonging to orders Lachnospirales and Oscillospirales. Pathway analysis of representative genomes of the FLI-associated taxa in (NCBI) Clostridium subclusters IV and XIVa indicated the presence of e.g., ethanol fermentation pathways. Through modeling the fatty liver index, our results provide with high resolution associations between gut microbiota composition and fatty liver in a large representative population cohort and support the role of endogenous ethanol producers in the development of fatty liver. |
| Databáze: | OpenAIRE |
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