The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
| Autor: | Francisco J. Barrantes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Neurosciences. Biological psychiatry. Neuropsychiatry Review Disease SARS-COV-2 Bioinformatics CEREBRO Capillary Beds Medicine MULTISYSTEMIC SYNDROME INFECCIONES Tropism General Environmental Science business.industry SARS-CoV-2 SISTEMA NERVIOSO CENTRAL NEUROTROPISMO COVID-19 Brain purl.org/becyt/ford/3.1 [https] central nervous system Pathophysiology NEUROLOGICAL MANIFESTATIONS COVID-19 Neurotropism Neurological complications Viral infection Etiology VIRUS General Earth and Planetary Sciences purl.org/becyt/ford/3 [https] business RC321-571 |
| Zdroj: | Brain, Behavior, & Immunity-Health, Vol 14, Iss, Pp 100251-(2021) CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Brain, Behavior, & Immunity-Health Brain, Behavior, & Immunity-Health Vol.14, 100251, 2021 Repositorio Institucional (UCA) Pontificia Universidad Católica Argentina instacron:UCA |
| ISSN: | 2666-3546 |
| Popis: | Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome is the main, but not the only manifestation of COVID-19. Necropsy studies are increasingly revealing underlying endothelial vasculopathies in the form of micro-haemorrhages and micro-thrombi. Intertwined with defective antiviral responses, dysregulated coagulation mechanisms, abnormal hyper-inflammatory reactions and responses, COVID-19 is disclosing a wide pathophysiological palette. An additional property in categorising the disease is the combination of tissue (e.g. neuro- and vasculo-tropism) with organ tropism, whereby the virus preferentially attacks certain organs with highly developed capillary beds, such as the lungs gastrointestinal tract, kidney and brain. These multiple clinical presentations confirm that the acute respiratory syndrome as described initially is increasingly unfolding as a more complex nosological entity, a multiorgan syndrome of systemic breadth. The neurological manifestations of COVID-19, the focus of this review, reflect this manifold nature of the disease. Fil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina |
| Databáze: | OpenAIRE |
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