The Effect of Streptomycin with Para-Amino Salicylic Acid on the Emergence of Resistant Strains of Tubercle Bacilli
| Autor: | Walter B. Brown, Jack Wallace, Edward Dunner |
|---|---|
| Rok vydání: | 1949 |
| Předmět: |
Prothrombin time
Bacillus (shape) Bacilli medicine.diagnostic_test Tubercle Bacillus Mycobacterium tuberculosis General Medicine Biology biology.organism_classification Aminosalicylic Acid In vitro Microbiology Lacticaseibacillus casei Diarrhea chemistry.chemical_compound chemistry Streptomycin medicine medicine.symptom Salicylic Acid Salicylic acid medicine.drug |
| Zdroj: | Diseases of the Chest. 16:661-666 |
| ISSN: | 0096-0217 |
| DOI: | 10.1378/chest.16.6.661 |
| Popis: | In a pilot study to observe the rate of development of resistant strains of tubercle bacilli by the use of streptomycin and para-aminosalicylic acid, it appears that development of such strains is delayed. Streptomycin-resistant tubercle bacilli are sensitive to para-aminosalicylic acid in vitro . Strains of tubercle bacilli in three patients appeared to develop resistance to para-aminosalicylic acid. This matter needs further investigation. Fifteen grams of para-aminosalicylic acid per day caused gastro intestinal disturbance with nausea, emesis and diarrhea. Blood levels ranged from 3 to 7 mgm. per cent four hours after PAS administration. Whether certain specific blood level maintenance is required for therapeutic efficacy requires further study. Prothrombin time was not altered by the above dosage. |
| Databáze: | OpenAIRE |
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