Sex Differences in Serum Markers of Major Depressive Disorder in the Netherlands Study of Depression and Anxiety (NESDA)
| Autor: | Brenda W.J.H. Penninx, Sabine Bahn, Cynthia Shannon Weickert, Femke Lamers, Paul C. Guest, Jordan M. Ramsey, Mariska Bot, Jason D. Cooper |
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| Přispěvatelé: | Neurosciences, Psychiatry, EMGO - Mental health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Male Physiology Peptide Hormones lcsh:Medicine Anxiety Logistic regression Pathology and Laboratory Medicine Biochemistry 0302 clinical medicine Endocrinology Medicine and Health Sciences Medicine Young adult lcsh:Science Immune Response Depression (differential diagnoses) Netherlands Sex Characteristics Multidisciplinary Depression Middle Aged C-Reactive Proteins Anxiety Disorders 3. Good health Major depressive disorder Female medicine.symptom Sex characteristics Research Article Adult medicine.medical_specialty Adolescent Inflammatory Diseases Immunology Neuropsychiatric Disorders Neuroses 03 medical and health sciences Young Adult Signs and Symptoms Neuroimaging Insulin-like Growth Factors Diagnostic Medicine Internal medicine Growth Factors Mental Health and Psychiatry Humans Aged Inflammation Depressive Disorder Major Endocrine Physiology business.industry Mood Disorders lcsh:R Biology and Life Sciences Proteins medicine.disease Hormones 030104 developmental biology lcsh:Q Tumor necrosis factor receptor 2 business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | PLoS ONE, Vol 11, Iss 5, p e0156624 (2016) PLoS One (print), 11(5). Public Library of Science PLoS ONE, 11(5). Public Library of Science Ramsey, J M, Cooper, J D, Bot, M, Guest, P C, Lamers, F, Weickert, C S, Penninx, B W J H & Bahn, S 2016, ' Sex Differences in Serum Markers of Major Depressive Disorder in the Netherlands Study of Depression and Anxiety (NESDA) ', PLoS ONE, vol. 11, no. 5 . https://doi.org/10.1371/journal.pone.0156624 PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0156624 |
| Popis: | Women have a consistently higher prevalence of major depressive disorder (MDD) than men. Hypotheses implicating hypothalamic-pituitary -adrenal, -gonadal, and -thyroid axes, immune response, genetic factors, and neurotransmitters have emerged to explain this difference. However, more evidence for these hypotheses is needed and new explanations must be explored. Here, we investigated sex differences in MDD markers using multiplex immunoassay measurements of 171 serum molecules in individuals enrolled in the Netherlands Study of Depression and Anxiety (N-MDD = 231; N-control = 365). We found 28 sex-dependent markers of MDD, as quantified by a significant interaction between sex and log(2-)transformed analyte concentration in a logistic regression with diagnosis (MDD/control) as the outcome variable (p < 0.05; q < 0.30). Among these were a number of male-specific associations between MDD and elevated levels of proteins involved in immune response, including C-reactive protein, trefoil factor 3, cystatin-C, fetuin-A, beta 2-microglobulin, CD5L, FASLG receptor, and tumor necrosis factor receptor 2. Furthermore, only male MDD could be classified with an accuracy greater than chance using the measured serum analytes (area under the ROC curve = 0.63). These findings may have consequences for the generalization of inflammatory hypotheses of depression to males and females and have important implications for the development of diagnostic biomarker tests for MDD. More studies are needed to validate these results, investigate a broader range of biological pathways, and integrate this data with brain imaging, genetic, and other relevant data. |
| Databáze: | OpenAIRE |
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