Insulin-like growth factor 1 gene (CA)n repeats and a variable number of tandem repeats of the insulin gene in Brazilian children born small for gestational age
| Autor: | Ana Elisa C. Billerbeck, Emilia M. Pinto, Elaine Maria Frade Costa, Ivo J.P. Arnhold, Berenice B. Mendonca, Carlos Alberto Longui, Margaret C. S. Boguszewski, Catarina Brasil d’Alva, Ricardo M. Garcia, Paulo R. Pachi, Alexander A. L. Jorge, Rocio R. D. Coletta |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Adenosine medicine.medical_treatment Growth Biology Insulin-like growth factor Cytosine Insulin resistance Risk Factors Small For Gestational Age Internal medicine Serum IGF1 Levels medicine Birth Weight Humans Insulin Allele Insulin-Like Growth Factor I lcsh:R5-920 Polymorphism Genetic IGF1 Gene Body Weight Infant Newborn Gestational age General Medicine Clinical Science medicine.disease Body Height Variable number tandem repeat VNTR of the Insulin Gene Endocrinology Tandem Repeat Sequences IGF1 Polymorphism Infant Small for Gestational Age Small for gestational age Female Insulin Resistance lcsh:Medicine (General) Body mass index Brazil |
| Zdroj: | Clinics; v. 68 n. 6 (2013); 785-791 Clinics; Vol. 68 Núm. 6 (2013); 785-791 Clinics; Vol. 68 No. 6 (2013); 785-791 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 68, Issue: 6, Pages: 785-791, Published: JUN 2013 Clinics, Vol 68, Iss 6, Pp 785-791 (2013) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: To investigate the influence of (CA)n repeats in the insulin-like growth factor 1 gene and a variable number of tandem repeats of the insulin gene on birth size in children who are small or adequate-sized for gestational age and to correlate these polymorphisms with serum insulin-like growth factor 1 levels and insulin sensitivity in children who are small for gestational age, with and without catch-up growth. PATIENTS AND METHODS: We evaluated 439 infants: 297 that were adequate-sized for gestational age and 142 that were small for gestational age (66 with and 76 without catch-up). The number of (CA)n repeat in the insulin-like growth factor 1 gene and a variable number of tandem repeats in the insulin gene were analyzed using GENESCAN software and polymerase chain reaction followed by enzymatic digestion, respectively. Clinical and laboratory data were obtained from all patients. RESULTS: The height, body mass index, paternal height, target height and insulin-like growth factor 1 serum levels were higher in children who were small for gestational age with catch-up. There was no difference in the allelic and genotypic distributions of both polymorphisms between the adequate-sized and small infants or among small infants with and without catch-up. Similarly, the polymorphisms were not associated with clinical or laboratory variables. CONCLUSION: Polymorphisms of the (CA)n repeats of the insulin-like growth factor 1 gene and a variable number of tandem repeats of the insulin gene, separately or in combination, did not influence pre- or postnatal growth, insulin-like growth factor 1 serum levels or insulin resistance. |
| Databáze: | OpenAIRE |
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