The Role of DNA Methylation in Ischemic Stroke: A Systematic Review
| Autor: | Jun Wu, Minyan Zeng, Jun Hu, Xiaonan Xu, Hongyan Qiu, Xiaodan Zheng, Zhijian Lin, Juanying Zhen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MEDLINE Ischemia review ischemic Bioinformatics lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine systematic medicine Epigenetics Stroke Pathological lcsh:Neurology. Diseases of the nervous system business.industry Methylation DNA medicine.disease stroke 030104 developmental biology Neurology DNA methylation Biomarker (medicine) Neurology (clinical) Systematic Review methylation business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neurology, Vol 11 (2020) Frontiers in Neurology |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2020.566124/full |
| Popis: | Background: Knowledge about the classic risk and protective factors of ischemic stroke is accumulating, but the underlying pathogenesis has not yet been fully understood. As emerging evidence indicates that DNA methylation plays a role in the pathological process of cerebral ischemia, this study aims to summarize the evidence of the association between DNA methylation and ischemic stroke. Methods: MEDLINE, EMBASE, PubMed, and Cochrane Central Register of Controlled Trials were searched for eligible studies. The results reported by each study were summarized narratively. Results: A total of 20 studies with 7,014 individuals finally met the inclusion criteria. Three studies focused on global methylation, 11 studies on candidate-gene methylation, and six on epigenome-wide methylation analysis. Long-interspersed nuclear element 1 was found to be hypomethylated in stroke cases in two studies. Another 16 studies reported 37 genes that were differentially methylated between stroke cases and controls. Individuals with ischemic stroke were also reported to have higher acceleration in Hanuum 's epigenetic age compared to controls. Conclusion: DNA methylation might be associated with ischemic stroke and play a role in several pathological pathways. It is potentially a promising biomarker for stroke prevention, diagnosis and treatment, but the current evidence is limited by sample size and cross-sectional or retrospective design. Therefore, studies on large asymptomatic populations with the prospective design are needed to validate the current evidence, explore new pathways and identify novel risk/protective loci. |
| Databáze: | OpenAIRE |
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