Angiopoietin-Like Protein 2 Is Associated With Chronic Kidney Disease in a General Japanese Population
| Autor: | Masaharu Nagata, Yasufumi Doi, Otowa Takahashi, Yuichi Oike, Yutaka Kiyohara, Jun Hata, Takanari Kitazono, Toshiharu Ninomiya, Tomoko Usui, Masayo Fukuhara |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Population Adipokine Renal function Gastroenterology Asian People Japan Risk Factors Internal medicine Prevalence medicine Albuminuria Humans Renal Insufficiency Chronic education Angiopoietin-Like Protein 2 Aged education.field_of_study business.industry General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Angiopoietin-like Proteins Cross-Sectional Studies Endocrinology Cardiovascular Diseases Female medicine.symptom Cardiology and Cardiovascular Medicine business Angiopoietins Kidney disease |
| Zdroj: | Circulation Journal. 77:2311-2317 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). METHODS AND RESULTS A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0mg/g) or decreased estimated glomerular filtration rate (eGFR |
| Databáze: | OpenAIRE |
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