Electrical wave propagation in an anisotropic model of the left ventricle based on analytical description of cardiac architecture
| Autor: | Vladimir S. Markhasin, Sergey F. Pravdin, Alexander V. Panfilov, Olga Solovyova, Hans Dierckx, Leonid B. Katsnelson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Physiology
Mathematical physiology Coordinate system Physics::Medical Physics lcsh:Medicine Rotation Muscle tissue Systems Science Ventricular Function Left Biophysics Theory ACTIVATION REENTRY Medicine and Health Sciences Myocytes Cardiac Anisotropy lcsh:Science Mathematical Computing Physics Excitable medium Numerical Analysis Multidisciplinary Wave propagation Applied Mathematics Models Cardiovascular EXCITABLE MEDIUM Heart Mechanics Epicardium Left ventricle Electrophysiology Fibers Filament drift Mathematics and Statistics TISSUE MODEL Ventricular Fibrillation Physical Sciences Interdisciplinary Physics FIBRILLATION Anatomy Pericardium Algorithms Research Article Computer Modeling Biophysical Simulations Computer and Information Sciences Scroll waves Quantitative Biology::Tissues and Organs Biophysics Cardiology FIBER ROTATION Filaments MECHANISMS Cardiovascular Physiological Phenomena Humans Computer Simulation Theoretical Biology Computerized Simulations VORTICES Curvilinear coordinates lcsh:R Electric Conductivity Cardiac Ventricle Biology and Life Sciences Computational Biology Computing Methods Nonlinear Dynamics Cardiovascular Anatomy lcsh:Q MYOCARDIUM Mathematics Endocardium |
| Zdroj: | PLoS ONE, Vol 9, Iss 5, p e93617 (2014) PLOS ONE PLoS ONE Plos One |
| ISSN: | 1932-6203 |
| Popis: | We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher–Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|