Hyperthyroidism and Hyperprolactinemia: Is There any Association?
| Autor: | Mojgan Sanjari, Khatereh Mohammadi Tahroodi, Zohreh Safi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine endocrine system medicine.medical_specialty Adolescent endocrine system diseases Cross-sectional study Endocrinology Diabetes and Metabolism Hyperthyroidism Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans 030212 general & internal medicine Young adult business.industry Age Factors Middle Aged Control subjects Confidence interval Prolactin Normal thyroid function Increased prolactin levels Hyperprolactinemia Cross-Sectional Studies 030104 developmental biology Female business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Endocrine Practice. 22:1377-1382 |
| ISSN: | 1530-891X |
| DOI: | 10.4158/ep161293.or |
| Popis: | To compare the serum prolactin level in hyperthyroid and normal control females. Hyperthyroidism is a common disease. Although a direct association has been demonstrated between hypothyroidism and increased prolactin levels, this association has not been established for hyperthyroidism.Cross-sectional study in cases and control groups. Control subjects were chosen from those participating in the Kerman Coronary Artery Disease Risk Factors study. To select the cases, all women referred to the laboratories of Kerman with a thyroid-stimulating hormone (TSH) level ≤0.5 mIU/L who met the inclusion criteria were entered in the study. A total of 231 women aged 15 to 50 years were enrolled. The case group included 71 hyperthyroid women, and the control group included 160 women with normal thyroid function matched by age.The mean (SD) serum level of prolactin was 16.56 (0.97) ng/mL (95% confidence interval [CI], 15.41 ng/mL to 15.71 ng/mL) in the controls and 23.07 (1.49) ng/mL (95% CI, 22.7 ng/mL to 23.4 ng/mL) in the case subjects. Hyperprolactinemia was more common in the hyperthyroid group (16.5 [0.97] ng/mL versus 23.07 [1.49] ng/mL; P.001). The prolactin level decreased with age. Hyperthyroidism and estradiol increased the prolactin level. After adjusting for age and estradiol, hyperthyroidism increased the serum prolactin level (P.001).The results of this study revealed that hyperprolactinemia is more frequent in hyperthyroid females. Serum prolactin level can be increased in hyperthyroidism.PRL = prolactin T4 = thyroxine TRH = thyrotropin-releasing hormone TSH = thyroid-stimulating hormone. |
| Databáze: | OpenAIRE |
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