Pulmonary actions of the neurokinin1-specific agonist [Sar9, Met(O2)11]-substance P
| Autor: | C. A. Yiamouyiannis, S. A. Silbaugh, P. W. Stengel, Sandra L. Cockerham |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Guinea Pigs Respiratory System Bronchi Substance P Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Evans Blue Lung Dose-Response Relationship Drug Pulmonary Gas Exchange Endocrine and Autonomic Systems business.industry Captopril General Medicine Thiorphan Receptors Neurokinin-1 respiratory system Airway obstruction Pulmonary edema medicine.disease Extravasation Trachea medicine.anatomical_structure Neurology chemistry Pulmonary Ventilation business Extravasation of Diagnostic and Therapeutic Materials medicine.drug |
| Zdroj: | Neuropeptides. 28:35-42 |
| ISSN: | 0143-4179 |
| Popis: | We examined the relationship between airway obstruction and plasma extravasation produced by the intravenous administration of the selective NK1 receptor agonist [Sar9, Met(O2)11]-substance P(SP). Conscious guinea-pigs were injected with Evans' blue dye followed by intravenous [Sar9,Met(O2)11]-SP. Animals were killed 3 min later and airway obstruction, determined via excised lung gas volumes, and plasma extravasation in the trachea, mainstem bronchi and intrapulmonary airways quantitated. Maximal plasma protein extravasation occurred at a dose about 30 times less than that required to elicit airway obstruction. Neither the neutral endopeptidase (NEP) inhibitor, thiorphan, or the angiotensin-converting enzyme (ACE) inhibitor, captopril, altered the extravasation response to [Sar9,Met(O2)11]-SP. However, thiorphan alone or combined with captopril produced a small but significant potentiation of the airway obstructive response. The marked difference between pulmonary gas trapping and Evans' blue extravasation responses suggest that [Sar9,Met(O2)11]-SP-induced airway obstruction is not secondary to increased pulmonary edema. |
| Databáze: | OpenAIRE |
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