Experiences with the ommaya reservoir for prophylaxis and treatment of the central nervous system in adult acute myelocytic leukemia
| Autor: | Simon Daenen, Hanny Haaxma-Reiche, Ron J. W. Witteveen |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Asymptomatic Catheters Indwelling Cerebrospinal fluid Internal medicine Meningeal Neoplasms medicine Ommaya reservoir Humans Meningitis Aged Injections Intraventricular Chemotherapy Hematology business.industry Remission Induction General Medicine Middle Aged medicine.disease Surgery Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Anesthesia Female Bone marrow medicine.symptom business Meningeal Leukemia |
| Zdroj: | Blut. 57:351-355 |
| ISSN: | 1432-0584 0006-5242 |
| DOI: | 10.1007/bf00320756 |
| Popis: | Intraventricular chemotherapy was administered to adult AML patients via an Ommaya reservoir. Twenty-eight patients received central nervous system (CNS) prophylaxis and seven patients were treated for meningeal leukemia (ML). A treatment course lasted at least 6 months. Asymptomatic ML developed in two patients (7%) of the prophylaxis group concomitantly with bone marrow relapse. One of these patients had not completed the standard course. CNS remission could be obtained in all evaluable patients with ML. The easy entrance to the cerebrospinal fluid (CSF) offers the advantage of frequent investigations of the CSF, early diagnosis and treatment of CNS relapses without radiotherapy, and caused little patient discomfort. CNS prophylaxis in this small study seemed to prolong first remission duration slightly. In M4 and M5 subtypes CNS prophylaxis can be valuable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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