Reduction of IL‐6 gene expression in human adipose tissue after sleeve gastrectomy surgery
| Autor: | Matthew J. Brady, Matthew J Piron, Jeremy M White, Isabel Casimiro, Ruby Ross, Avelino De Leon, Erin C. Hanlon, Katiannah Moise |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine obesity medicine.medical_specialty bariatric surgery Endocrinology Diabetes and Metabolism Adipose tissue 030209 endocrinology & metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Immune system Weight loss Internal medicine Adipocyte parasitic diseases medicine Macrophage lcsh:RC31-1245 Interleukin 6 030109 nutrition & dietetics Nutrition and Dietetics biology business.industry Interleukin Original Articles medicine.disease macrophages Endocrinology chemistry interleukin‐6 biology.protein Original Article medicine.symptom business |
| Zdroj: | Obesity Science & Practice Obesity Science & Practice, Vol 6, Iss 2, Pp 215-224 (2020) |
| ISSN: | 2055-2238 |
| Popis: | Summary Objective There is increasing evidence that immune cell interactions in adipose tissue contribute to the development of metabolic dysfunction. Pro‐inflammatory cytokines have been shown to mediate insulin resistance, and the presence of macrophages is a salient feature in the development of obesity. The present study aimed to evaluate adipocyte size and macrophage activation in women before and 3 months after laparoscopic vertical sleeve gastrectomy (VSG). Methods Subcutaneous abdominal adipose tissue biopsies were obtained from women scheduled to undergo VSG. Histological evaluation of adipocytes and macrophages was performed as well as cytokine expression quantification before and after VSG‐induced weight loss. Results Weight loss following VSG resulted in a reduction in adipocyte size as well as a decrease in interleukin (IL)‐6 cytokine mRNA expression in subcutaneous adipose tissue. There was no change in the presence of crownlike structures after weight loss. Conclusions Early weight loss after VSG is associated with a reduction in adipocyte size and a decline in IL‐6 gene expression in local adipose tissue. Macrophage infiltration and crownlike density structures persist in adipose tissue from tissues impacted by excess body weight 3 months after VSG‐induced weight loss. |
| Databáze: | OpenAIRE |
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