Transport and biological activities of bile acids
| Autor: | Luis B. Agellon, Brittnee L. Zwicker |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Gut flora
Fatty Acid-Binding Proteins digestive system Biochemistry Fatty acid-binding protein Bile Acids and Salts Gastrointestinal Hormones chemistry.chemical_compound Enterohepatic Circulation Intestine Small medicine Humans Intestinal Mucosa Enterohepatic circulation Regulation of gene expression biology Cholesterol Transporter Biological Transport Cell Biology FABP6 biology.organism_classification Small intestine medicine.anatomical_structure Enterocytes chemistry Gene Expression Regulation Liver Hepatocytes |
| Zdroj: | The international journal of biochemistrycell biology. 45(7) |
| ISSN: | 1878-5875 |
| Popis: | Bile acids have emerged as important biological molecules that support the solubilization of various lipids and lipid-soluble compounds in the gut, and the regulation of gene expression and cellular function. Bile acids are synthesized from cholesterol in the liver and eventually released into the small intestine. The majority of bile acids are recovered in the distal end of the small intestine and then returned to the liver for reuse. The components of the mechanism responsible for the recycling of bile acids within the enterohepatic circulation have been identified whereas the mechanism for intracellular transport is less understood. Recently, the ileal lipid binding protein (ILBP; human gene symbol FABP6) was shown to be needed for the efficient transport of bile acids from the apical side to the basolateral side of enterocytes in the distal intestine. This review presents an overview of the transport of bile acids between the liver and the gut as well as within hepatocytes and enterocytes. A variety of pathologies is associated with the malfunction of the bile acid transport system. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect