Association of Expression of CD44v6 With Systemic Anaplastic Large Cell Lymphoma
| Autor: | Xiayuan Liang, Loren E. Golitz, Sara A. Williams, Lorrie F. Odom, Bruce R. Smoller, Sandra J. Meech, John Ryder |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Adolescent Primary cutaneous anaplastic large cell lymphoma Risk Assessment Immunophenotyping Predictive Value of Tests hemic and lymphatic diseases medicine Humans Anaplastic lymphoma kinase Anaplastic Lymphoma Kinase Child Anaplastic large-cell lymphoma Anaplasia Aged Glycoproteins Retrospective Studies biology business.industry CD44 Receptor Protein-Tyrosine Kinases General Medicine Middle Aged Protein-Tyrosine Kinases medicine.disease Immunohistochemistry Lymphoma Hyaluronan Receptors Child Preschool Disease Progression biology.protein Female Lymphoma Large B-Cell Diffuse medicine.symptom business |
| Zdroj: | American Journal of Clinical Pathology. 117:276-282 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | CD44 is a ubiquitous multifunctional cell surface adhesion molecule family. High expression of the standard form, CD44s (CD44), and its variant form, CD44v6, has been reported to be associated with tumor dissemination in non-Hodgkin lymphoma. To evaluate the potential role of CD44 and/or CD44v6 in different entities of anaplastic large cell lymphoma (ALCL), 30 cases of systemic ALCL (sALCL; 20 cases) and primary cutaneous ALCL (cALCL; 10 cases) were compared for expression of CD44 and CD44v6 by immunohistochemical staining. Expression of CD44v6 also was analyzed with respect to expression of anaplastic lymphoma kinase (ALK) in sALCL. No difference of CD44 expression was noted between sALCL and cALCL. In contrast, expression of CD44v6 was found in 18 (90%) of sALCL cases and in 5 (50%) of cALCL cases. There was no correlation between expression of CD44v6 and expression of ALK in sALCL. These results indicate that expression of CD44v6 rather than CD44 correlates with sALCL. Furthermore, these results suggest that CD44v6 and ALK may be independent predictors of risk for the systemic phenotype of ALCL. |
| Databáze: | OpenAIRE |
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