Dopachrome tautomerase (Dct) regulates neural progenitor cell proliferation
| Autor: | Faith M. Strickland, Ann Hozeska, Rui Lan Zhang, Cynthia Roberts, Zheng Gang Zhang, Ying Wang, Lei Wang, Thomas J. Hornyak, Michael Chopp, Zhongxian Jiao |
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| Rok vydání: | 2006 |
| Předmět: |
Male
SVZ progenitor Mouse Rostral migratory stream Neurogenesis SOX10 Melanoma Experimental Subventricular zone Mice Transgenic Neocortex Biology Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Melanoblast medicine Animals Progenitor cell Molecular Biology Cells Cultured Cell Proliferation 030304 developmental biology Neurons Genetics 0303 health sciences Stem Cells Brain Cell Biology Neural stem cell Cell biology Intramolecular Oxidoreductases body regions medicine.anatomical_structure NIH 3T3 Cells Dopachrome tautomerase Cortical neural progenitor cell 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Biology. 296:396-408 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2006.06.006 |
| Popis: | DOPAchrome tautomerase (Dct) functions downstream of tyrosinase in the biosynthetic pathway of eumelanin by catalyzing the conversion of dopachrome to 5,5-dihydroxyindole-2-carboxylic acid (DHICA) in pigment cells. Dct transcription is regulated directly or synergistically by Pax3, Sox10 and microphthalmia transcription factor (MITF). Using Dct-lacZ transgenic mice, we measured the spatial and temporal pattern of Dct expression in vivo during neocortical neurogenesis in the brain. Dct was expressed in all layers of the dorsal telencephalon in E10.5. At E15.5 and E17.5 when cortical neurogenesis occurs, expression of Dct was primarily localized to the ventricular zone (VZ) where neuronal stem cells reside. Blocking endogenous Dct by RNAi decreased proliferation of embryonic cortical neural progenitor cells (by 48%, P |
| Databáze: | OpenAIRE |
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