Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate
| Autor: | Javier García-Campayo, Eva Andrés, Juan V. Luciano, Nicolás Fayed, Rosa Magallón, Julián Beltrán, Helena Andrés-Bergareche |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Fibromyalgia Glutamine Immunology Glutamic Acid Pain Cholic Acid behavioral disciplines and activities Hippocampus chemistry.chemical_compound Nuclear magnetic resonance Neuroimaging Rheumatology Fractional anisotropy Effective diffusion coefficient Choline Medicine Immunology and Allergy Humans Inositol Nuclear Magnetic Resonance Biomolecular Aspartic Acid business.industry Motor Cortex Brain Somatosensory Cortex Middle Aged medicine.disease Cross-Sectional Studies Diffusion Tensor Imaging Editorial nervous system chemistry Biochemistry Female Protons business Research Article Diffusion MRI |
| Zdroj: | Arthritis Research & Therapy |
| ISSN: | 1478-6362 |
| Popis: | Introduction The purpose of this study was to investigate whether single-voxel (SV) proton magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI) detected differences between fibromyalgia (FM) patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables. Methods Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination, DWI, DTI, and proton MRS were performed on the brain areas known to be associated with pain processing. Results Compared with healthy controls, FM patients had significantly higher levels of glutamate + glutamine (Glx) (mean ± SD, 10.71 ± 0.50 arbitrary institutional units versus 9.89 ± 1.04; P = 0.049) and higher glutamate + glutamine/creatine (Glx/Cr) ratios (1.90 ± 0.12 versus 1.72 ± 0.23; P = 0.034) in the posterior gyrus. Myoinositol (Ins) levels of the right and left hippocampi were significantly lower in FM patients (4.49 ± 0.74 versus 5.17 ± 0.62; P = 0.008 and 4.91 ± 0.85 versus 6.09 ± 0.78; P = 0.004, respectively). In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Significant correlations between depression, pain, and global function and the posterior gyrus Glx levels and Glx/Cr ratios were observed. Conclusions Glx within the posterior gyrus could be a pathologic factor in FM. Hippocampal dysfunction may be partially responsible for the depressive symptoms of FM. Additional studies with larger samples are required to confirm these preliminary data. |
| Databáze: | OpenAIRE |
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