Homocysteine-Induced Oxidative Damage: Mechanisms and Possible Roles in Neurodegenerative and Atherogenic Processes
| Autor: | E. H. Schlüssel, G Preibisch, Erich F. Elstner, S Pütter |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Homocysteine Arteriosclerosis Swine Context (language use) medicine.disease_cause Models Biological General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Methionine Malate Dehydrogenase Internal medicine Blood plasma medicine Animals Aspartate Aminotransferases Thermus Monophenol Monooxygenase Basidiomycota Myocardium Alanine Transaminase medicine.disease Dihydroxyphenylalanine Hemolysis Enzymes Kinetics Oxidative Stress Endocrinology chemistry Biochemistry Pyridoxal Phosphate Low-density lipoprotein Nervous System Diseases Oxidation-Reduction Oxidative stress |
| Zdroj: | Zeitschrift für Naturforschung C. 50:699-707 |
| ISSN: | 1865-7125 0939-5075 |
| DOI: | 10.1515/znc-1995-9-1017 |
| Popis: | Increased blood plasma concentrations of the sulphur amino acid homocysteine (“homocysteinemia”) have been brought into context with neurodegenerative and arteriosclerotic symptoms and diseases. We recently reported on biochemical model reactions on the prooxidative activity of hom ocysteine including the desactivation of Na+/K+-ATPases and hemolysis of erythrocytes (Preibisch et al., 1993). In this communication we extend our model reactions including the oxidation of methionine, metabolization of pyridoxalphosphate and dihydroxyphenylalanine, desactivations of transaminases and peroxidation of low density lipoprotein |
| Databáze: | OpenAIRE |
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