Reorganization of the Connectivity of Cortical Field DZ in Congenitally Deaf Cat
| Autor: | Ludovic Lacassagne, Andrej Kral, Pascal Barone |
|---|---|
| Přispěvatelé: | Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Auditory Neuroscience & Neuroprostheses, Hanover Medical School |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Nerve net lcsh:Medicine Otology Deafness Biology Audiology Auditory cortex Somatosensory system Injections 03 medical and health sciences 0302 clinical medicine Stimulus modality Neuroimaging Psychophysics medicine otorhinolaryngologic diseases Animals lcsh:Science Hearing Disorders Vision Ocular 030304 developmental biology Auditory Cortex Neurons 0303 health sciences Multidisciplinary CATS Staining and Labeling Crossmodal lcsh:R Sensory Systems medicine.anatomical_structure Auditory System Otorhinolaryngology Cats Medicine Sensory Perception lcsh:Q [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Sensory Deprivation Nerve Net 030217 neurology & neurosurgery Research Article Neuroscience Lateral Thalamic Nuclei |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e60093. ⟨10.1371/journal.pone.0060093⟩ PLoS ONE, Vol 8, Iss 4, p e60093 (2013) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0060093⟩ |
| Popis: | International audience; Psychophysics and brain imaging studies in deaf patients have revealed a functional crossmodal reorganization that affects the remaining sensory modalities. Similarly, the congenital deaf cat (CDC) shows supra-normal visual skills that are supported by specific auditory fields (DZ-dorsal zone and P-posterior auditory cortex) but not the primary auditory cortex (A1). To assess the functional reorganization observed in deafness we analyzed the connectivity pattern of the auditory cortex by means of injections of anatomical tracers in DZ and A1 in both congenital deaf and normally hearing cats. A quantitative analysis of the distribution of the projecting neurons revealed the presence of non-auditory inputs to both A1 and DZ of the CDC which were not observed in the hearing cats. Firstly, some visual (areas 19/20) and somatosensory (SIV) areas were projecting toward DZ of the CDC but not in the control. Secondly, A1 of the deaf cat received a weak projection from the visual lateral posterior nuclei (LP). Most of these abnormal projections to A1 and DZ represent only a small fraction of the normal inputs to these areas. In addition, most of the afferents to DZ and A1 appeared normal in terms of areal specificity and strength of projection, with preserved but smeared nucleotopic gradient of A1 in CDCs. In conclusion, while the abnormal projections revealed in the CDC can participate in the crossmodal compensatory mechanisms, the observation of a limited reorganization of the connectivity pattern of the CDC implies that functional reorganization in congenital deafness is further supported also by normal cortico-cortical connectivity. |
| Databáze: | OpenAIRE |
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