Pineal and Adrenal Effects on Calcium Homeostasis in the Rat
| Autor: | William H Bergstrom, David O Hakanson |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Light medicine.medical_treatment Parathyroid hormone chemistry.chemical_element Propranolol Calcium Pineal Gland Melatonin chemistry.chemical_compound Corticosterone Internal medicine Adrenal Glands medicine Animals Homeostasis Calcium metabolism Hypocalcemia Metyrapone Adrenalectomy Phosphorus Rats Inbred Strains Rats Calcium Dietary Endocrinology Animals Newborn chemistry Pediatrics Perinatology and Child Health hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Pediatric Research. 27:571-573 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-199006000-00006 |
| Popis: | In human infants and newborn rats, white light at the intensity used to treat hyperbilirubinemia lowers serum calcium concentration. Occipital shielding or (in newborn rats) exogenous melatonin prevents this effect. Propranolol, by inhibiting melatonin synthesis, also causes hypocalcemia, which is preventable by melatonin. Metyrapone or adrenalectomy prevents hypocalcemia after light exposure or propranolol. Exogenous corticosterone lowers serum calcium; this is prevented by supplementary melatonin. In adult rats, the change in calcium after light, propranolol, or corticosterone is minimal. After parathyroidectomy or a diet with a high calcium/low phosphorus ratio, the hypocalcemic effect of these three agents is restored. Bone samples removed after light exposure or corticosterone administration show increased calcium uptake; this is blocked by supplementary melatonin in vivo or by addition of melatonin to the incubation medium. We postulated that the hypocalcemic effect of light or propranolol was due to an acute increase in corticosterone-mediated bone calcium uptake when circulating melatonin was decreased by reduction of the rate of melatonin synthesis. In our study, pinealectomized rats showed no change in serum calcium after light or propranolol; their hypocalcemic response to corticosterone was greater than that of shamoperated controls. Exogenous parathyroid hormone prevented light-induced hypocalcemia in newborn rats. |
| Databáze: | OpenAIRE |
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