Implication of Microsatellite Instability Pathway in Outcome of Colon Cancer in Moroccan Population

Autor: Mohamed El Abkari, Karim Ouldim, Chbani Laila, Zineb Benbrahim, Nada Lahmidani, Wadih Moukit, Hicham El Bouhaddouti, Karima El Rhazi, Karim Ibn Majdoub Hassani, Abdelmalek Oussaden, S. Bennis, Ihssane El Otmani, Sidhi Adil Ibrahimi, Fatima El Agy, Nawfal Mellas, Imane Toughrai, Asmae Mazti, Khalid Maazaz, Sanae El Bardai, Khalid Ait Taleb, El Bachir Benjelloun
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Oncology
Neuroblastoma RAS viral oncogene homolog
Male
Colorectal cancer
Clinical Biochemistry
medicine.disease_cause
DNA Mismatch Repair
0302 clinical medicine
Lymph node
Aged
80 and over
education.field_of_study
lcsh:R5-920
General Medicine
Middle Aged
Prognosis
Morocco
medicine.anatomical_structure
030220 oncology & carcinogenesis
Colonic Neoplasms
Female
Microsatellite Instability
KRAS
lcsh:Medicine (General)
Research Article
Adult
medicine.medical_specialty
Article Subject
Population
Context (language use)
03 medical and health sciences
Young Adult
Internal medicine
Genetics
medicine
Humans
education
Molecular Biology
neoplasms
Survival analysis
Aged
Neoplasm Staging
business.industry
Biochemistry (medical)
Microsatellite instability
medicine.disease
Survival Analysis
digestive system diseases
030104 developmental biology
business
Zdroj: Disease Markers
Disease Markers, Vol 2019 (2019)
ISSN: 1875-8630
0278-0240
Popis: Background. Tumors with microsatellite instability (MSI tumors) have distinct clinicopathological features. However, the relation between these tumor subtypes and survival in colon cancer remains controversial. The aim of this study was to evaluate the overall survival (OS) in patients with MSI phenotype, in FES population. Methods. The expression of MMR proteins was evaluated by immunohistochemistry for 330 patients. BRAF, KRAS, and NRAS mutations were examined by Sanger sequencing and pyrosequencing methods. The association of MSI status with a patient’s survival was assessed by the Kaplan–Meier method and log-rank test. Results. The mean age was 54.6 years (range of 19-90 years). The MSI status was found in 11.2% of our population. MSI tumors were significantly associated with male gender, younger patients, stage I-II, right localization, and a lower rate of lymph node and distant metastasis. The OS tends to be longer in MSI tumors than MSS tumors (109.71 versus 74.08), with a difference close to significance (P=0.05). Conclusion. Our study demonstrates that MSI tumors have a particular clinicopathological features. The results of survival analysis indicate that the MSI status was not predictive of improved overall survival in our context with a lower statistical significance (P=0.05) after multivariate analysis.
Databáze: OpenAIRE
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