Serum Lipoperoxide Level Variations in Normal and Luteal Phase Defect Cycles
| Autor: | L Scarpellini, M. Mastrone, Fabio Scarpellini, M Sbracia |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Ovulation
Infertility Lipid Peroxides medicine.medical_specialty media_common.quotation_subject Statistical difference Luteal Phase Biology Luteal phase Internal medicine medicine Humans Progesterone Menstrual cycle media_common Estradiol Significant difference Obstetrics and Gynecology medicine.disease Endocrinology Reproductive Medicine Female Who classification Infertility Female Hormone |
| Zdroj: | Gynecologic and Obstetric Investigation. 42:28-30 |
| ISSN: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000291884 |
| Popis: | A luteal phase defect (LPD) is a clinical problem leading to infertility and is characterized by reduced progesterone levels during the luteal phase. Serum lipoperoxidation is an expression of cellular hypoxic damage occurring under all stress-oxidative conditions. Forty-eight consecutive infertility patients, according to the infertility class II of the WHO classification, underwent clinical observation. Twenty-five patients ovulated constantly with a normal luteal phase, while the other 23 had a LPD, hormonally and histologically assessed. The luteal phase was monitored biochemically by titration of progesterone, oestradiol, and serum lipid peroxides during the ovulatory period and 6-12 days after ovulation. The mean plasmatic concentration of oestradiol was not statistically different between the LPD and the normal-cycle groups, while a statistically significant difference was found for progesterone plasmatic concentrations between the LPD and the normal-cycle groups (p < 0.05); a greater statistical difference was also found in the mean serum lipoperoxide titration (p < 0.001). These findings suggest that serum lipoperoxidation titration may be a useful tool in the study of the interactions between hormonal milieu and sympathetic activity. |
| Databáze: | OpenAIRE |
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