Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites
| Autor: | Oliver T. Fackler, Ulrich S. Schwarz, Lucas Schütz, Johanna Ripp, Mendi J. Muthinja, Tamás Haraszti, Joachim P. Spatz, Janina Kristin Hellmann, Noa Dahan, Friedrich Frischknecht, Anna Battista, Leandro Lemgruber |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Plasmodium berghei Biomedical Engineering Pharmaceutical Science 02 engineering and technology Plasmodium Biomaterials Apicomplexa 03 medical and health sciences parasitic diseases medicine Animals Humans Tropism biology 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification 3. Good health Cell biology Culicidae 030104 developmental biology medicine.anatomical_structure Sporozoites Microvessels Immunology sense organs 0210 nano-technology Blood stream Malaria Blood vessel |
| Zdroj: | Advanced Healthcare Materials |
| ISSN: | 2192-2640 |
| DOI: | 10.1002/adhm.201601178 |
| Popis: | Plasmodium sporozoites, the highly motile forms of the malaria parasite, are transmitted naturally by mosquitoes and traverse the skin to find, associate with, and enter blood capillaries. Research aimed at understanding how sporozoites select blood vessels is hampered by the lack of a suitable experimental system. Arrays of uniform cylindrical pillars can be used to study small cells moving in controlled environments. Here, an array system displaying a variety of pillars with different diameters and shapes is developed in order to investigate how Plasmodium sporozoites associate to the pillars as blood vessel surrogates. Investigating the association of sporozoites to pillars in arrays displaying pillars of different diameters reveals that the crescent-shaped parasites prefer to associate with and migrate around pillars with a similar curvature. This suggests that after transmission by a mosquito, malaria parasites may use a structural tropism to recognize blood capillaries in the dermis in order to gain access to the blood stream. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text