Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia

Autor: Zhengtao Wang, Bai-Xiang Cai, Yue Zhou, Li Yang, Hai-Jun Hu, Leixin Song, Zhu-Zhen Han
Rok vydání: 2020
Předmět:
Zdroj: Natural Product Research. 35:5120-5124
ISSN: 1478-6427
1478-6419
DOI: 10.1080/14786419.2020.1782404
Popis: Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC50 values 26.3 and 27.7 μM, comparable to that of the positive control.
Databáze: OpenAIRE
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