Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia
Autor: | Zhengtao Wang, Bai-Xiang Cai, Yue Zhou, Li Yang, Hai-Jun Hu, Leixin Song, Zhu-Zhen Han |
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Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Natural Product Research. 35:5120-5124 |
ISSN: | 1478-6427 1478-6419 |
DOI: | 10.1080/14786419.2020.1782404 |
Popis: | Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory activities with IC50 values 26.3 and 27.7 μM, comparable to that of the positive control. |
Databáze: | OpenAIRE |
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