Intraoperative Local Ablative Therapies Combined with Surgery for the Treatment of Bilobar Colorectal Liver Metastases
| Autor: | Roberto Santambrogio, Micol Polizzi, Enrico Opocher, Matteo Barabino, Andrea Gatti, Carmelo Luigiano |
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| Rok vydání: | 2017 |
| Předmět: |
Ablation Techniques
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Local ablation Thermal ablation Gastroenterology Resection 03 medical and health sciences 0302 clinical medicine Internal medicine Ablative case medicine Hepatectomy Humans Aged Univariate analysis Tumor size business.industry Liver Neoplasms General Medicine Middle Aged Survival Analysis Tumor recurrence Tumor Burden Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Neoplasm Recurrence Local business Colorectal Neoplasms Adjuvant |
| Zdroj: | Anticancer research. 37(5) |
| ISSN: | 1791-7530 |
| Popis: | AIM To investigate the role of intraoperative local ablation techniques (LATs) in bilobar colorectal liver metastases (bCRLM). PATIENTS AND METHODS Among patients who underwent LAT for CRLM between 2005 and 2015, we selected 33 patients with bilobar disease submitted to thermal ablation alone or associated to liver resection. Primary end-point was complete local response at one month (CLR). Secondary end-points were morbidity, mortality, disease-free survival (DFS), local tumor recurrence (LTR) and long-term survival. RESULTS CLR was observed in 100% of cases, while LTR occurred in 8 cases (22%). DFS at 1, 3 and 5 years was 37%, 5% and 5%. Overall survival (OS), in the same interval, was 95%, 49% and 26%. Univariate analysis found a significant correlation between LTR and tumor size (11% ≤20 mm vs. 50% >20 mm; p=0.009). CONCLUSION LAT is an effective adjuvant strategy in bCRLM for nodules within 20 mm diameter. |
| Databáze: | OpenAIRE |
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