Vitamin E status and its determinants in patients with cystic fibrosis
| Autor: | Patrycja Krzyżanowska-Jankowska, Wojciech Skorupa, Ewa Wenska-Chyży, Jarosław Walkowiak, Andrzej Pogorzelski, Mariusz Szczepanik, Szczepan Cofta, Dariusz Walkowiak, Ewa Sapiejka |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Adolescent Cystic Fibrosis medicine.medical_treatment Cystic fibrosis Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Vitamin E Medicine Vitamin E Deficiency 030212 general & internal medicine Tocopherol Child business.industry Infant Newborn Albumin General Medicine Middle Aged medicine.disease Fat-Soluble Vitamin 030228 respiratory system Quartile Child Preschool Linear Models Female Vitamin E deficiency business |
| Zdroj: | Advances in Medical Sciences. 63:341-346 |
| ISSN: | 1896-1126 |
| DOI: | 10.1016/j.advms.2018.04.001 |
| Popis: | Purpose The risk of vitamin E deficiency is of primary concern in cystic fibrosis patients. However, early diagnosis and routine vitamin E supplementation can lead to its normal or even high levels. In the present study, we assessed vitamin E status in a large group of cystic fibrosis patients. Moreover, we also aimed to establish determinants of its body resources in cystic fibrosis patients. Material and methods The study group comprised 211 cystic fibrosis patients aged from 1 month to 48 years. In all of them serum α-tocopherol concentration was analyzed using high-performance liquid chromatography. Results Median vitamin E concentration was 9.9 μg/ml (1st–3rd quartile: 7.5–13.5). Vitamin E deficiency was found in 17 (8.0%) and high levels were documented in 24 (11.4%) participants. Patients with and without vitamin E deficiency did not differ significantly with respect to age, standardized body weight and height, FEV1, albumin concentration and vitamin E supplementation dose. However, vitamin E deficiency appeared more frequently in participants without vitamin E supplementation. Moreover, in multiple linear regression analysis pancreatic insufficiency, severe CFTR gene mutation and vitamin E dose, were potentially defined as determinants of vitamin E concentration. Conclusions Vitamin E deficiency in cystic fibrosis patients is rather rare nowadays. Excessive vitamin E levels seem to be more frequent. Vitamin E status wasn’t documented to be strictly related to clinical determinants. Beyond vitamin E supplementation, exocrine pancreatic function and CFTR gene mutations may have had an impact on the vitamin E body resources in cystic fibrosis patients. |
| Databáze: | OpenAIRE |
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