Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides

Autor: Cintia Miranda dos Santos, Carlos Alexandre Carollo, José Benedito Perrella Balestieri, Jaqueline Ferreira Campos, Edson Lucas dos Santos, Leticia M. Estevinho, Helder Freitas dos Santos, Denise Brentan Silva, Kely de Picoli Souza
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Aging
Antioxidant
Erythrocytes
medicine.medical_treatment
medicine.disease_cause
Biochemistry
Antioxidants
Terpene
chemistry.chemical_compound
0302 clinical medicine
Anti-Infective Agents
Malondialdehyde
Free-radicals
Chromatography
High Pressure Liquid
lcsh:Cytology
General Medicine
Antimicrobial
Hemolysis
3. Good health
030220 oncology & carcinogenesis
Melipona quadrifasciata
Research Article
Article Subject
Hyaluronoglucosaminidase
Brazilian propolis
Saccharomyces cerevisiae
Biology
Gram-Positive Bacteria
Propolis
03 medical and health sciences
Antioxidant activity
Botany
Gram-Negative Bacteria
medicine
Animals
lcsh:QH573-671
Flavonoids
Cell Biology
medicine.disease
Hymenoptera
Enzyme assay
Antibacterial
Oxidative Stress
030104 developmental biology
chemistry
biology.protein
Oxidative stress
Zdroj: Oxidative Medicine and Cellular Longevity
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
ISSN: 1942-0994
1942-0900
Popis: Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections. This work was supported by grants from Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Universidade Federal da Grande Dourados (UFGD), and PRODER (24.073 – Â, Portugal). info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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