Balloon-occluded chemoembolization for hepatocellular carcinoma: a prospective study of safety, feasibility and outcomes
| Autor: | Jean-Luc Van Laethem, Martina Pezzullo, Raphael Leveque, Gontran Verset, Illario Tancredi, Simona Picchia, AM Bucalau |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Abdominal pain 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Interquartile range medicine polyethylene glycol embolizing microspheres balloon-occluded transarterial chemoembolization using drug-eluting microspheres Transcatheter arterial chemoembolization Prospective cohort study Adverse effect Hepatology business.industry hepatocellular carcinoma medicine.disease Oncology Response Evaluation Criteria in Solid Tumors Hepatocellular carcinoma 030211 gastroenterology & hepatology Radiology medicine.symptom Complication business Research Article transcatheter arterial chemoembolization |
| Zdroj: | Hepatic Oncology |
| ISSN: | 2045-0931 2045-0923 |
| Popis: | Aim: Evaluation of safety and efficacy of selective balloon-occluded transarterial chemoembolization using polyethylene glycol embolizing microspheres in patients with hepatocellular carcinoma. Materials & methods: Twenty-four consecutive patients were included in this monocentric prospective trial. Adverse events were evaluated at 24 h and 1 month. Imaging response according to modified response evaluation criteria in solid tumors was assessed at 1, 3 and 6 months. Results: The median time of follow-up was of 22.8 months (interquartile range (IQR) 17.38–26.22). Clinical grade 1/2 toxicities (0% >grade 2) were reported in 25.7% of patients, with abdominal pain being the most frequent complication (17.1%). No 30-days mortalities or liver decompensation were observed. The 1-month follow-up MRI showed an overall response rate of 74.3%. Conclusion: Balloon-occluded transarterial chemoembolization was shown to be safe and effective. Tweetable abstract We report a new technique of chemoembolization for liver cancer that allows to selectively treat tumor nodules with fewer side effects and better tolerance. #chemoembolizationforHCC #improvinglocoregionaltreatmentinHCC #balloonmicrocatheterforTACE |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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