The schistosome excretory system: a key to regulation of metabolism, drug excretion and host interaction
| Autor: | Paul McVeigh, J. Thornhill, John R. Kusel |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
ATP Binding Cassette Transporter Subfamily B Praziquantel Host-Parasite Interactions Excretion In vivo parasitic diseases Animals Humans Lung Skin Anthelmintics biology Nephridiopore Biological Transport Helminth Proteins Schistosoma mansoni Metabolism biology.organism_classification Drug Resistance Multiple In vitro Cell biology Infectious Diseases Excretory system Immunology Female Parasitology Trematoda |
| Zdroj: | Trends in Parasitology. 25:353-358 |
| ISSN: | 1471-4922 |
| DOI: | 10.1016/j.pt.2009.05.003 |
| Popis: | There is a gulf between the enormous information content of the various genome projects and the understanding of the life of the parasite in the host. In vitro studies with adult Schistosoma mansoni using several substrates suggest that the excretory system contains both P-glycoproteins and multiresistance proteins. If both these families of protein were active in vivo, they could regulate parasite metabolism and be responsible for the excretion of drugs. During skin penetration, membrane-impermeant molecules of a wide range of molecular weights can be taken into the cercaria and schistosomulum through the nephridiopore, through the surface membrane or through both. We speculate that this uptake process might stimulate novel signalling pathways involved in growth and development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect