Synthetic studies toward the marine metabolite prorocentin-4: synthesis of the C1-C23 fragment
| Autor: | Sandeep AnkiReddy, Praveen AnkiReddy, Sabitha Gowravaram |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Primary (chemistry) 010405 organic chemistry Fragment (computer graphics) Stereochemistry Metabolite Organic Chemistry Epoxide Alcohol 010402 general chemistry 01 natural sciences Biochemistry Aldehyde 0104 chemical sciences Catalysis chemistry.chemical_compound Polyketide chemistry Physical and Theoretical Chemistry |
| Zdroj: | Organicbiomolecular chemistry. 16(22) |
| ISSN: | 1477-0539 |
| Popis: | A synthetic study of the construction of the C1–C23 fragment of prorocentin-4, a novel linear polyketide, is described. The synthetic highlights include the acid catalyzed epoxide opening, Gilman reaction, Pd(OH)2 catalyzed transformation of a primary propargylic alcohol into an aldehyde, Oxa-Michael cyclization, and Horner–Wadsworth–Emmons (HWE) olefination reaction as key steps. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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