VITAMIN B12 ABSORPTION TEST AND ORAL TREATMENT IN 14 CHILDREN WITH SELECTIVE VITAMIN B12 MALABSORPTION
| Autor: | Cigdem Altay, Ihsan Dogramaci, Mualla Cetin |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Oral treatment Malabsorption Anemia Administration Oral Absorption (skin) Gastroenterology Malabsorption Syndromes Oral administration Internal medicine medicine Humans Vitamin B12 Vitamin B12 absorption test Child business.industry Infant Hematology medicine.disease Vitamin B 12 Endocrinology Intestinal Absorption Oncology Case-Control Studies Pediatrics Perinatology and Child Health Oral vitamin business |
| Zdroj: | Pediatric Hematology and Oncology. 16:159-163 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.1080/088800199277489 |
| Popis: | Oral vitamin B12 (VB12) absorption was studied in 12 patients with selective VB12 malabsorption and in 6 age-matched healthy controls. Serum VB12 level was measured before and 3 h after oral administration of VB12 100 or 1000 micrograms. After administration of 1000 micrograms of VB12 an appreciable increase in the serum VB12 level was observed in patients as well as in controls. The mean of the increase in the serum VB12 level did not differ between patients and the controls (273 +/- 203 pg/mL, 180 +/- 71 pg/mL, respectively P.05). Twelve patients previously treated by parenteral VB12 were switched to, and 2 newly diagnosed patients were started on, oral VB12 treatment of 1000 micrograms given every 2 weeks. Hematological parameters and serum VB12 levels remained stable after switching to oral therapy in the 12 patients. In the two newly diagnosed patients anemia was cured by orally administrated VB12. This study lends further support to the use of megadoses of VB12 as an alternative treatment for selective VB12 malabsorption. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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