Transient effect of mossy fiber stimulation on spatial firing of CA3 neurons
| Autor: | Eunjae Cho, Joonyeup Lee, Min Whan Jung, Jong Won Lee, Doyun Lee, Miru Yun |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Mossy fiber (hippocampus)
Male Cognitive Neuroscience Long-Term Potentiation Place cell Hippocampus Action Potentials Stimulation Mice Transgenic Optogenetics Synaptic Transmission 050105 experimental psychology 03 medical and health sciences Mice 0302 clinical medicine Memory formation Premovement neuronal activity Animals 0501 psychology and cognitive sciences Hippocampal mossy fiber Chemistry musculoskeletal neural and ocular physiology Pyramidal Cells 05 social sciences Excitatory Postsynaptic Potentials CA3 Region Hippocampal nervous system Mossy Fibers Hippocampal Synapses Transient (oscillation) Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Hippocampus. 29(7) |
| ISSN: | 1098-1063 |
| Popis: | Strong hippocampal mossy fiber synapses are thought to function as detonators, imposing ‘teaching’ signals onto CA3 neurons during new memory formation. For an empirical test of this long-standing view, we examined effects of stimulating mossy fibers on spatial firing of CA3 neurons in freely-moving mice. We found that optogenetic stimulation of mossy fibers can alter CA3 spatial firing, but their effects are only transient. Spatially restricted mossy fiber stimulation, either congruent or incongruent with CA3 place fields, was more likely to suppress than enhance CA3 neuronal activity. Also, changes in spatial firing induced by optogenetic stimulation reverted immediately upon stimulation termination, leaving CA3 place fields unaltered. Our results do not support the traditional view that mossy fibers impose teaching signals onto CA3 network, and show robustness of established CA3 spatial representations. |
| Databáze: | OpenAIRE |
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