In Vitro Effects of Clopidogrel on the Platelet-Subendothelium Interaction, Platelet Thromboxane and Endothelial Prostacyclin Production, and Nitric Oxide Synthesis
| Autor: | A. Guerrero, Araceli Pinacho, José Pedro De La Cruz, M.A. Villalobos, Felipe Sánchez de la Cuesta, M. M. Arrebola |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Platelets Male Ticlopidine Antiplatelet drug Platelet Aggregation Thromboxane medicine.medical_treatment Prostacyclin Pharmacology Nitric Oxide Thienopyridines medicine Humans Platelet cardiovascular diseases Platelet activation Cells Cultured Aspirin Chemistry Middle Aged Clopidogrel Epoprostenol Thromboxane B2 Biochemistry Cardiology and Cardiovascular Medicine Platelet Aggregation Inhibitors circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 43:74-82 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200401000-00012 |
| Popis: | Clopidogrel is an antiplatelet drug that belongs to the group of thienopyridines. Because of its main mechanism of action most studies of clopidogrel have centered on the platelet ADP pathway. The aim of the present study was to compare the effects of clopidogrel, ticlopidine, and aspirin, on platelet activation by collagen (the main inducer of platelet activation in vivo), prostanoid, and NO production, and the effects on blood perfusion experiments. Clopidogrel inhibited platelet aggregation induced in whole blood by collagen and TxB2 production to a greater extent than did ticlopidine. Prostacyclin synthesis did not change after incubation with thienopyridines, whereas aspirin inhibited synthesis in a dose-dependent manner. Thienopyridines increased NO production to a greater extent than did aspirin. All three drugs impaired the platelet-subendothelium interaction under flow conditions. With thienopyridines, the presence of endothelium did not modify the percentage of the surface coated by platelets. |
| Databáze: | OpenAIRE |
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