Efficacy and safety of a single monthly dose of cholecalciferol in healthy school children
| Autor: | Sunil Kumar Mishra, Mohammad Shafi Kuchay, Ambrish Mithal, Navin Dang, Ganesh Jevalikar |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Endocrinology Diabetes and Metabolism Administration Oral 030209 endocrinology & metabolism Drug Administration Schedule vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Vitamin D and neurology Humans Medicine 030212 general & internal medicine Vitamin D Child Dose-Response Relationship Drug Vitamin d supplementation business.industry Case-control study Follow up studies Prognosis Vitamin D Deficiency medicine.disease Regimen chemistry Case-Control Studies Dietary Supplements Pediatrics Perinatology and Child Health Female Safety business Cholecalciferol Residential school Follow-Up Studies |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 29 |
| ISSN: | 2191-0251 0334-018X |
| DOI: | 10.1515/jpem-2015-0187 |
| Popis: | This study aimed to evaluate the efficacy and safety of a single monthly dose of cholecalciferol in healthy school children.A total of 118 children of class VI of a residential school were selected to receive vitamin D supplementation in the form of oral cholecalciferol 60,000 IU monthly. Serum calcium and 25-hydroxyvitamin D (25OHD) levels were estimated at 0 and 12 months. The proportion of subjects achieving vitamin D sufficiency was assessed.The mean 25OHD levels increased significantly from 12.04±5.27 ng/mL at baseline to 32.6±7.05 ng/mL after 12 months of supplementation (pVitamin D supplementation in the doses of 60,000 IU monthly is a reasonable, safe and cost-effective regimen for children to attain and maintain vitamin D sufficiency. |
| Databáze: | OpenAIRE |
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