Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in Saudi Arabia

Autor: Heba Kamal Morsi, Hassan Abdelaziz Hassan Gaber, Amani Abdelhamid Elbasmy, Manar Mohammad Ismail
Rok vydání: 2015
Předmět:
0301 basic medicine
Adult
Blood Glucose
medicine.medical_specialty
Article Subject
Cross-sectional study
Thiobarbituric acid
Immunology
Saudi Arabia
medicine.disease_cause
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
Diabetes mellitus
Internal medicine
Malondialdehyde
lcsh:Pathology
medicine
Humans
Macrophage Migration-Inhibitory Factors
Aged
Glycated Hemoglobin
business.industry
Cholesterol
HDL
Case-control study
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
Cell Biology
Cholesterol
LDL
Fasting
Middle Aged
medicine.disease
Healthy Volunteers
030104 developmental biology
Cross-Sectional Studies
chemistry
Diabetes Mellitus
Type 2
Case-Control Studies
Clinical Study
Macrophage migration inhibitory factor
lipids (amino acids
peptides
and proteins)
business
Oxidative stress
Biomarkers
lcsh:RB1-214
Zdroj: Mediators of Inflammation
Mediators of Inflammation, Vol 2016 (2016)
ISSN: 1466-1861
Popis: Background. Malondialdehyde (MDA) has been implicated in the development of many acute inflammatory, autoimmune diseases as well as chronic inflammatory metabolic disorders. Involvement of inflammatory response and oxidative stress is currently suggested as a mechanism underlying development of diabetes and its complications.Objective. To evaluate the clinical utility of MDA, macrophage migration inhibitory factor (MIF), LDL-C/HDL-C, and TG/HDL-C ratio as noninvasive laboratory markers for prediction of T2DM vascular complications.Method. 63 Saudi T2DM patients and 16 age and sex matched controls were included. Serum MDA and MIF were assayed by thiobarbituric acid reactive substances and ELISA, respectively. TG/HDL-C and LDL-C/HDL-C ratios were calculated.Results. Uncontrolled DM patients had significantly higher levels of MDA, MIF, TG/HDL-C, and LDL-C/HDL-C ratios when compared with controlled DM patients and control group (p<0.001). MDA had 100% sensitivity and 88% specificity. MIF showed 97% sensitivity and 100% specificity and LDL-C/HDL-C had 97% sensitivity and 95% specificity. Meanwhile, TG/HDL-C had the lowest sensitivity and specificity in identifying diabetic patients who would suffer from vascular complications.Conclusion. MDA, MIF, and LDL-C/HDL-C could be new predictors of metabolic disturbance which promote vascular complications in T2DM.
Databáze: OpenAIRE
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