Prevalence of GCK mutations in individuals screened for fasting hyperglycaemia
| Autor: | Rury R. Holman, Irene M Stratton, L. Lonie, M van de Bunt, L. Tucker, Sian Ellard, Anna L. Gloyn |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Glycosuria medicine.medical_specialty Diabetes risk Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Overweight Body Mass Index Impaired glucose tolerance Insulin-Secreting Cells Internal medicine Diabetes mellitus Glucokinase Ethnicity Internal Medicine medicine Humans business.industry Insulin Fasting Middle Aged medicine.disease Endocrinology Diabetes Mellitus Type 2 Hyperglycemia Mutation Female medicine.symptom business |
| Zdroj: | Diabetologia. 52:172-174 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-008-1188-4 |
| Popis: | Keywords Fastingplasmaglucose.Genetics.Glucokinase.MODY.PredictionAbbreviationsDHPLC denaturing high performance liquidchromatographyEDIT Early Intervention Diabetes TrialFHS Fasting Hyperglycaemia StudyGCK-MODY glucokinase MODY2HPGI 2-hour post-challenge plasma glucoseincrementTo the Editor: Glucokinase is a key enzyme that regulatesinsulinsecretionbychangingbetacellglucosephosphorylationrates over the range of physiological glucose concentrations[1]. Inactivating mutations in the gene encoding glucokinase(GCK), as seen in glucokinase MODY (GCK-MODY), shiftthe threshold value for glucose-stimulated insulin secretionfrom ∼5to∼7 mmol/l, resulting in elevated fasting plasmaglucose (FPG) levels (5.5–8.0 mmol/l) but normal (typically |
| Databáze: | OpenAIRE |
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