Oral premedication in patients with a history suggesting hypersensitivity to iodinated contrast media
| Autor: | Marta Chełmińska, Ewa Jassem, Lucyna Górska, Beata Wajda, Krzysztof Specjalski |
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| Rok vydání: | 2020 |
| Předmět: |
contrast media allergy
premedication medicine.medical_treatment Context (language use) Dermatology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Prednisone medicine Immunology and Allergy Adverse effect Internal medicine Original Paper business.industry RC31-1245 iodinated contrast media Cetirizine Hypersensitivity reaction RL1-803 Anesthesia Itching Antihistamine Premedication medicine.symptom business drug hypersensitivity medicine.drug |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii Advances in Dermatology and Allergology, Vol 37, Iss 4, Pp 520-523 (2020) |
| ISSN: | 1642-395X |
| Popis: | Introduction Iodinated contrast media (ICM) are pharmaceuticals widely used in diagnostic procedures. Adverse effects associated with their administration are quite frequent and mostly mild. However, they raise concerns in patients and doctors in the context of their future use. Aim To determine efficacy of premedication before medical procedures with the use of iodinated contrast media in patients with a history suggesting a hypersensitivity reaction after their past use. Material and methods Out of 152 patients consulted due to adverse reactions after ICM (85 women and 67 men, aged 43-90), 101 were selected with the history suggesting a mild hypersensitivity reaction (urticaria, itching, skin redness, malaise etc.). All the patients had health problems requiring a procedure with ICMadministration in the near future. The premedication was given with cetirizine (10 mg) and prednisone (20 mg or 50 mg, randomly assigned) 13, 7 and 1 h before the ICM administration. Presence of adverse events was compared between the subgroups with χ 2 test and efficacy of premedication - with Wilcoxon test. Results Seventy-six patients underwent the radiologic procedure with premedication with antihistamine and a lower (40 patients) or higher dose (36 patients) of prednisone. Four of them reported a cutaneous hypersensitivity reaction (urticaria, itching, redness) and one - dyspnoea. There was no statistically significant difference in relation to the premedication protocol (p = 0.1306). Conclusions Premedication with cetirizine and prednisone before radiologic procedures proved to be efficient in patients with a history suggesting hypersensitivity to iodinated contrast media. There was no significant difference in efficacy related to the dose of prednisone (20 mg vs. 50 mg). |
| Databáze: | OpenAIRE |
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