Persistent moderate to severe pain and long‐term cognitive decline
| Autor: | Cheng Zhang, Zhenchun Yang, Song-Hua Xiao, Fanfan Zheng, Wei Rong, Wuxiang Xie |
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| Rok vydání: | 2021 |
| Předmět: |
Aging
medicine.medical_specialty Longitudinal study business.industry Pain Cognition Middle Aged Standard score Article Anesthesiology and Pain Medicine Cohort Physical therapy medicine Humans Population study Cognitive Dysfunction Female Longitudinal Studies Prospective Studies Cognitive decline Verbal memory business Aged Cohort study |
| Zdroj: | Eur J Pain |
| ISSN: | 1532-2149 1090-3801 |
| DOI: | 10.1002/ejp.1826 |
| Popis: | BACKGROUND The longitudinal association between persistent moderate to severe pain and subsequent long-term cognitive decline remains inconclusive. METHODS Study population came from the English Longitudinal Study of Ageing, an ongoing prospective and nationally representative cohort of community-dwelling adults aged ≥50 years in England. At waves 1 (2002/2003) and 2 (2004/2005) of the study, pain severity was measured based on pain intensity scores ranged from 0 to 10. We defined moderate to severe pain as pain intensity scores ≥5 points. Persistent moderate to severe pain was defined as participants reported moderate to severe pain at both waves 1 and 2. Standardized global cognitive Z scores derived from verbal memory, temporal orientation and semantic fluency were used as the primary outcome. RESULTS A total of 6,869 individuals (3,896 women; mean age: 63.9 ± 9.5 years) who have accepted twice measurements of pain at waves 1 and 2 (baseline), and at least one reassessment of cognitive function at waves 3 (2006/2007) to 8 (2016/2017), were included in this study. Each 5-point increase in the sum of pain intensity scores was associated with a faster rate of -0.009 (95% CI: -0.013 to -0.006, p |
| Databáze: | OpenAIRE |
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