Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness
| Autor: | Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas, Judith Allanson, John D. Pickard, Guy B. Williams, Michael M. Craig, Paola Finoia, Alexander R. D. Peattie, Peter Coppola, Adrian M. Owen, Lorina Naci, David K. Menon, Daniel Bor, Emmanuel A. Stamatakis |
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| Přispěvatelé: | Pickard, John [0000-0002-5762-6667], Apollo - University of Cambridge Repository, Luppi, Andrea I [0000-0002-3461-6431], Mediano, Pedro AM [0000-0003-1789-5894], Rosas, Fernando E [0000-0001-7790-6183], Pickard, John D [0000-0002-5762-6667], Williams, Guy B [0000-0001-5223-6654], Finoia, Paola [0000-0002-3908-9255], Peattie, Alexander RD [0000-0003-2115-7640], Coppola, Peter [0000-0002-8658-7409], Owen, Adrian M [0000-0002-5738-3765], Naci, Lorina [0000-0001-9630-3978], Menon, David K [0000-0002-3228-9692], Stamatakis, Emmanuel A [0000-0001-6955-9601], Luppi, Andrea [0000-0002-3461-6431], Williams, Guy [0000-0001-5223-6654], Menon, David [0000-0002-3228-9692], Stamatakis, Emmanuel [0000-0001-6955-9601] |
| Rok vydání: | 2022 |
| Předmět: |
Life Sciences & Biomedicine - Other Topics
631/378/116/1925 Consciousness Medicine (miscellaneous) Unconsciousness General Biochemistry Genetics and Molecular Biology MECHANISMS CEREBRAL-CORTEX Humans Anesthesia Biology Propofol Science & Technology LESIONS NETWORK DYNAMICS article Brain FUNCTIONAL CONNECTIVITY 631/378/116/2392 Multidisciplinary Sciences INSIGHTS 631/378/116/2393 631/378/2649/1398 VEGETATIVE STATE 59/78 59/57 Science & Technology - Other Topics 59/36 DELIRIUM General Agricultural and Biological Sciences Life Sciences & Biomedicine INTEGRATION INADEQUATE EMERGENCE |
| Zdroj: | Neuroscience Institute Publications |
| Popis: | Funder: Evelyn Trust; doi: https://doi.org/10.13039/501100004282 Funder: James S. McDonnell Foundation (McDonnell Foundation); doi: https://doi.org/10.13039/100000913 Funder: Canadian Institute for Advanced Research (L'Institut Canadien de Recherches Avancées) The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness (DOC). Here, we sought to identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead to common reconfigurations of neural activity. We developed and systematically perturbed a neurobiologically realistic model of whole-brain haemodynamic signals. By incorporating PET data about the cortical distribution of GABA receptors, our computational model reveals a key role of spatially-specific local inhibition for reproducing the functional MRI activity observed during anaesthesia with the GABA-ergic agent propofol. Additionally, incorporating diffusion MRI data obtained from DOC patients reveals that the dynamics that characterise loss of consciousness can also emerge from randomised neuroanatomical connectivity. Our results generalise between anaesthesia and DOC datasets, demonstrating how increased inhibition and connectome perturbation represent distinct neurobiological paths towards the characteristic activity of the unconscious brain. |
| Databáze: | OpenAIRE |
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